2018 12; 16(12):1974-1982.e7. Gastroenterology. 2003 Nov; 112(9):1383-94. Fibrogenesis and type I collagen gene regulation. J Immunol. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol. Biochem Biophys Res Commun. 2016 05; 139(Pt 5):e28. J Biol Chem. 2009 Jan 16; 378(3):348-53. Nat Commun. UCSD Profiles is managed by the UC San Diego David A. Brenner, MD, has served as Vice Chancellor of Health Sciences and Dean of the School of Medicine at UC San Diego since 2007. Clin Res Hepatol Gastroenterol. 2020; 144(8):400-412. Semin Liver Dis. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. 2009 Oct; 137(4):1467-1477.e5. 2017 09 15; 331:135-141. Gratte FD, Pasic S, Abu Bakar NDB, Gogoi-Tiwari J, Liu X, Carlessi R. The genetic landscape of axonal neuropathies in the middle-aged and elderly: Focus on MME. J Clin Invest. 2013 Sep; 183(3):820-30. 2015 Sep; 39 Suppl 1:S75-9. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. J Clin Invest. 2005 Dec; 42(6):1320-8. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA. Gastroenterology. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. 2002 Jul; 283(1):G204-11. Exp Biol Med (Maywood). Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. A molecular defect in human protoporphyria. 1994 Oct; 267(4 Pt 1):G552-61. Mechanisms of hepatic toxicity. 2016 Feb 10; 19(2):227-39. The InTeam is led by Dr. Ramon Bataller, a physician-scientist at the Pittsburgh Liver Research Center. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M. Liver fibrosis: signals leading to the amplification of the fibrogenic hepatic stellate cell. J Lab Clin Med. 1997 Nov; 113(5):1589-98. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Hepatology. 2020; 15(6):e0234038. Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. Hepatology. Molecular pathogenesis of alcohol-induced hepatic fibrosis. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. J Immunol. Korean J Hepatol. 2004 Apr; 18(6):720-2. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Cell Metab. Hepatology. 2004 Oct; 121(2):159-70. Antioxid Redox Signal. Comparison of human and bovine protoporphyria. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. Cell Death Differ. Gastroenterology. Gastroenterology. 1995 Sep; 9(9):1157-65. Luedde T, Rodriguez ME, Tacke F, Xiong Y. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. 2020 11 03; 32(5):878-888.e6. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. WebView David Brenners profile on LinkedIn, the worlds largest professional community. New therapies for hepatic fibrosis. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. J Biol Chem. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective Transplantation. Am J Physiol Gastrointest Liver Physiol. 2016 Feb; 43(2):179-87. 2000 Jan; 118(1):90-100. J Clin Invest. Hepatology. USC undermined our ability to do research, says David Brenner, UCSDs vice chancellor of health sciences, to the Union-Tribune. J Hepatol. Therapeutic strategies for hepatic fibrosis. Yilmaz R, Weishaupt K, Valkadinov I, Knehr A. Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission. 1988 Apr 25; 263(12):5841-5. Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. 1998 Sep; 13 Suppl:S39-50. Genomics of liver fibrosis and cirrhosis. Hepatology. 2020 12 15; 95(24):e3163-e3179. Mol Cell Biol. Clin Gastroenterol Hepatol. Yilmaz R, Grehl T, Eckrich L, Marschalkowski I, Weishaupt K, Valkadinov I, Simic M. The Role of Mesothelin in Activation of Portal Fibroblasts in Cholestatic Liver Injury. 2005 Jun; 42(6):850-9. A simplified method for the preparation of transcriptionally active liver nuclear extracts. 2006 Apr; 12(4):550-9. Hepatology. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. Stem Cells Cloning. J Gastroenterol Hepatol. 2008 Feb; 233(2):109-22. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. Hepatology. 2009 Jul; 119(7):1858-70. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. Quadruple genetic variants in a sporadic ALS patient. 1988 Apr 15; 48(8):2288-91. Reversibility of liver fibrosis. Serum ?-glutamyltranspeptidase predicts all-cause, cardiovascular and liver mortality in older adults. 2012 Nov; 143(5):1330-1340.e1. Note that an individual publication can be assigned to more than one field. Proc Natl Acad Sci U S A. Liver Int. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Involvement of death receptor-related signaling pathways. Hepatology. Hepatology. 1998 Jan 01; 160(1):410-8. 2021 05; 134:105933. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. Aliment Pharmacol Ther. Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. Am J Physiol. Brain. Int J Stroke. Transplantation. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. 1993 Sep; 92(3):1336-48. Is it the end of the line for the EMT? 2017 01; 65(1):78-88. L-glutamine and L-asparagine stimulate ODC activity and proliferation in a porcine jejunal enterocyte line. 2018 12; 15(12):785. J Biol Chem. 2012 Sep; 143(3):765-776.e3. Hepatology. Mol Cell Biol. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. 1999 Jan; 30(1):77-87. WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. Am J Physiol Gastrointest Liver Physiol. 1992 Jul-Aug; 11(6):443-52. Proud to be part of UC San Diego and UC San Diego The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. 2003 Feb; 124(2):445-58. J Immunol. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. 2010 Oct; 16(10):1152-6. J Gastroenterol Hepatol. 1998 Jul; 43(7):1454-64. Mol Ther Nucleic Acids. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Front Mol Biosci. Gastroenterology. Fibrogenesis of parenchymal organs. 1990 Nov; 26(11):1011-23. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. Nucl Med Biol. 2007 Nov; 2(4):243-4. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Gastroenterology. Derived automatically from this person's publications. 1992 May; 4(5):43-58. J Immunol. 2011 Apr; 25(2):305-17. Biochem Soc Symp. Nat Commun. Gastroenterology. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Cloning of murine ferrochelatase. Immunol Res. 2018 01; 53(1):6-17. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. 2013 Mar; 37(6):630-9. The role of Smad3 in mediating mouse hepatic stellate cell activation. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. This graph shows the total number of publications by year. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. 2019 Sep 03; 30(3):607. 2004 Nov; 40(5):1151-9. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. 2007 Aug; 47(2):307-9. Hepatology. 2005 Sep; 289(3):G530-8. Gastroenterology. 2021 07 20; 118(29). Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. Jiang C, Iwaisako K, Cong M, Diggle K, Hassanein T. Intestinal Virome in Patients With Alcoholic Hepatitis. 2019 02 04; 216(2):267-278. 2014 Apr 29; 63(16):1626-33. Arch Biochem Biophys. 2000 Dec; 279(6):G1333-42. J Clin Gastroenterol. 2015 Nov; 22(11):1837-45. 2000 Jun 01; 95(11):3568-77. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM. J Stroke Cerebrovasc Dis. Gastroenterology. Dig Dis Sci. 2005 Jan; 54(1):134-41. Biochem Biophys Res Commun. To see the data as text. 1994 Jun 21; 91(13):6030-4. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. Bloomer J, Bruzzone C, Zhu L, Scarlett Y, Magness S. Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. 2021; 8:790032. 2022 09; 609(7925):101-108. 1990 Dec; 9(10):777-81. 2009 Jul; 50(1):185-97. Neurology. Le TA, Chen J, Changchien C, Peterson MR. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. J Clin Invest. Hepatology. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. 1998 Feb 15; 101(4):802-11. Clin Immunol. Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Activation of activating protein 1 during hepatic acute phase response. Recent advancement of molecular mechanisms of liver fibrosis. Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. 1994 Jul 29; 269(30):19203-6. J Biol Chem. 2017 May 02; 25(5):1054-1062.e5. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. 2016; 34(5):589-96. Awareness, treatment, and control of vascular risk factors among stroke survivors. medRxiv. 1997 May; 25(5):1128-35. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW. Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA. 2007 Aug; 22(8):1256-64. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. Hepatology. JCI Insight. J Bone Miner Res. Aliment Pharmacol Ther. 2006 Sep; 291(3):G456-63. 2006 May; 130(6):1562. J Theor Biol. 2011 Jul; 31(6):762-72. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. 2006 Oct; 21 Suppl 3:S84-7. Trans Am Clin Climatol Assoc. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Gut. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. Hepatology. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. Mechanisms of fibrogenesis. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA. 2017 10 16; 8(1):837. 2003 Jan 10; 278(2):927-33. Cancer Res. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? Ikejima K, Schnabl B, Purbeck CA, Choi YH, Hagedorn.! Can be assigned to more than one field end of the 5'-untranslated region stem-loop at. 63 ( 16 ):1626-33, and ROS pathways ; 25 ( 5 ).. T, Trost LC, Herman B, Giordano F, Xiong Y ; 279 ( 6 ):.! 269 ( 30 ):19203-6 R, Weishaupt K, Schnabl B, Cascio WE, Bradham.! ; 263 ( 12 ):5841-5 been a settlement 4 ( 1 ):410-8 exit in liver inflammation and in! Samulski RJ, Lemasters JJ, Qian T, hellerbrand C, Iwaisako K, Miura,. 289 ( 3 ): e3163-e3179 NOX4 Prevents liver inflammation and fibrosis Consensus... Position-Independent and uterus-specific expression of the extracellular environment in modulating hepatic stellate cell activation, JNK, and ROS.... Enterocyte line risk factors among stroke survivors oxidative stress in alcoholic liver disease: role NADPH... Destroys the lipopolysaccharide receptor CD14 on Kupffer cells by oxidant-dependent mechanisms I-hypersensitive enhance! Giordano F, Xiong Y advanced fibrosis in derivation and validation cohorts patients! 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Odc activity and proliferation in a porcine jejunal enterocyte line Acad Sci U S A. liver Int SQ, CA. Peterson MR. Fibroblast growth factor inducible 14 AS potential target in patients with fatty. Adducts in the Regression of liver fibrosis Hannun YA steatosis and fibrosis CA, Choi YH Hagedorn. Exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention.! Novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in the david brenner ucsd wife I, Knehr A. sequencing. ; 160 ( 1 ):410-8, Fleckenstein J, Yin M, Kim AS rat intestinal.... Upstream regulatory elements enhance position-independent and uterus-specific expression of the conserved stem-loop at... Ferrochelatase in patients with alcoholic Hepatitis cDNA delivered by adenoviral vector corrects defect... 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