A diagnosis of inflammatory breast cancer is confirmed by breast imaging, breast core biopsy and a skin punch biopsy. 11th ed. Trends in inflammatory breast carcinoma incidence and survival: the surveillance, epidemiology, and end results program at the National Cancer Institute. Overmeyer B and Pierce LJ. Clinical Cancer Research 2013; 19(17):4685-96. It is important, therefore, that women who are diagnosed with inflammatory breast cancer talk with their doctor about the option of participating in a clinical trial. The pathology and molecular pathogenesis of IBC are presented separately. Additional information about clinical trials is available online. This are skin disorders that produces sings similar to those of rash caused by allergies and insect bites on the breast area. Symptoms of inflammatory breast cancer include swelling (edema) and redness (erythema) that affect a third or more of the breast. Obesity linked to 21 genes related to Alzheimers disease, study finds, What to know about Paget's disease of the breast. Outcomes after multidisciplinary treatment of inflammatory breast cancer in the era of neoadjuvant HER2-directed therapy. Lymph vessels collect and filter lymph, a clear fluid that contains white blood cells and flows throughout the body's lymphatic system. Symptoms include rapid increase in size of breast, breast pain, reddening and pitting or dimpling of breast skin. Your doctor examines your breast to look for redness and other signs of inflammatory breast cancer. Inflammatory breast cancer is a high-grade aneuploid cancer, with mutations and overexpression of p53, high levels of E-cadherin and abnormal cadherin function. People who seek care at Mayo Clinic also have access to the latest treatments being studied in clinical trials. Similar to TNBC, as opposed to hormone receptor-positive breast cancer, there is a high rate of relapse and . 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Why does inflammatory breast cancer cause a rash? There are a handful of other conditions can share symptoms with inflammatory breast cancer, including the following: Mastitis is a condition characterized by inflammation and infection of the breast tissue. How to Spot and Treat a Breast Cancer Rash. Inflammatory breast cancer (IBC) is a rare but rapidly growing cancer that gives rise to several signs and symptoms, mostly within a span of three to six months. Idiopathic granulomatous mastitis is a rare condition, discharge, which may be white, green-black, or grey, patting yourself dry after bathing and avoid rubbing the skin, avoiding sun exposure to the affected area, avoiding perfumes, deodorants, and other products that could aggravate the rash, asking a doctor or pharmacist about products to relieve pain and itching, seeking medical advice for an unfamiliar rash. It's a pinkish brown color bruise I guess. In Vora SR, ed. Risk factors for inflammatory breast cancer and other invasive breast cancers. It can lead to a rash around one or both of your nipples. All rights reserved. Most inflammatory breast cancers are invasive ductal carcinomas, which means they developed from cells that line the milk ducts of the breast and then spread beyond the ducts. Once this happens, prompt treatment is needed. Weve invested more than $5 billion in cancer research since 1946, all to find more and better treatments, uncover factors that may cause cancer, and improve cancer patients quality of life. IBC usually has no noticeable symptoms until skin changes become noticeable. This might mean a punch biopsy of the breast skin that is abnormal. This article explains when a rash could be cancerous and what else can cause a breast rash. It is typically a very aggressive disease and is called "inflammatory" because the cancer cells block the lymphatic vessels, resulting in changes in the breast (swelling and redness) that make the breast appear to be inflamed, resembling an infection in the breast ().Over 250,000 women in the United States are diagnosed . Changes in breast size or appearance, pain or tenderness, enlarged lymph nodes, or changes in the skin texture or nipple appearance are common symptoms of inflammatory breast cancer. Kalra MG, Higgins KE, Kinney BS. (Medical Images) Inflammatory breast cancer (IBC) is an aggressive, fast-growing type of breast cancer. Infections, allergies, heatstroke, viruses, and stress can all cause rashesand so can breast cancer. If youve noticed sudden changes to your breasts and are concerned that it may be IBC, schedule an appointment with a doctor as soon as possible. What celebrities have or have had breast cancer? Also, because inflammatory breast cancer is so aggressive, it can arise between scheduled screening mammograms and progress quickly. At diagnosis, inflammatory breast cancer is either stage III or IV disease, depending on whether cancer cells have spread only to nearby lymph nodes or to other tissues as well. Inflammatory breast cancer is aggressive and fast-growing breast cancer in which cancer cells infiltrate the skin and lymph vessels of the breast. Is hair dye linked to a higher risk of breast cancer? Symptoms. Many of these symptoms develop quickly, usually within a period of 3 to 6 months. It also tends to affect women at a younger age than other breast cancers. 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Dawood S, Cristofanilli M. Inflammatory breast cancer: what progress have we made? Annals of Oncology 2014; 25(2):384-91. Taghian A and Merajver SD. These rashes tend to occur with less common or more aggressive types of breast cancer. However, they can sometimes be an early sign of inflammatory breast cancer or. National Comprehensive Cancer Network (NCCN). Symptoms include raised, red bumps or welts and itchy skin. Long-term treatment efficacy in primary inflammatory breast cancer by hormonal receptor- and HER2-defined subtypes. Version 7.2021. Inflammatory breast tumors are frequently. Healthline Media does not provide medical advice, diagnosis, or treatment. Often, there is no lump that can be felt during a physical exam or seen in a screening mammogram. Common symptoms may include: IBC symptoms are caused by a blockage of the lymphatic system within the breast, which causes pain and swelling. Disease-free and overall survival after pathologic complete disease remission of cytologically proven inflammatory breast carcinoma axillary lymph node metastases after primary systemic chemotherapy. Few early symptoms may include new lump in the underarm or in breast, itching or discharge from the nipples, and skin texture . If you have a breast rash, speak with your healthcare provider so they can run diagnostic tests to determine the cause and treat the underlying condition. All rights reserved. Fouad TM, Kogawa T, Reuben JM, Ueno NT. Retrieved April 18, 2012. Unlike other common breast cancers, it often does not cause a breast lump. Shingles (herpes zoster). Want to use this content on your website or other digital platform? The disease typically occurs in women younger than 40. Inflammatory breast cancer is a rare and aggressive form of breast cancer. Could a monthly antibody injection be a promising endometriosis treatment? Inflammatory breast cancer symptoms result from a buildup of fluid in your breast. Is there a link between hormone replacement therapy (HRT) and breast cancer? Initial biopsy samples from the affected breast show invasive carcinoma. A breast rash can indicate inflammatory breast cancer (IBC), a rare, aggressive cancer that often goes undetected. In certain cases, other gene mutations (changes) or proteins might be tested for to see if specific drugs might be helpful. In other cases, it's a symptom of a common, treatable skin condition. All rights reserved. This type of breast cancer is called "inflammatory . Inflammatory Breast Cancer. Inflammatory breast cancer is uncommon, accounting for .5% to 2% of all breast cancers. The skin also may appear ridged or pitted, which is called peau d'orange . You can help reduce your risk of cancer by making healthy choices like eating right, staying active and not smoking. The American Cancer Society medical and editorial content team. Painful, itchy blisters that result from the same virus that causes chickenpox. (There is no localized SEER stage for IBC since it has already reached the skin when first diagnosed.). This type of breast cancer is called inflammatory because the breast often looks swollen and red, or inflamed. "The reason the breast becomes red and hot is the breast cancer cells are clogging the little lymphatic vessels that drain the skin and so they get clogged up . Treatment is necessary and usually includes draining the abscess and antibiotics. A relative survival rate compares women with the same type and stage of breast cancer to women in the overall population. A doctor may also carry out tests to rule out breast cancer and diabetes. Here are some therapies your doctor may include in your treatment plan: At Another Johns Hopkins Member Hospital: Masks are required inside all of our care facilities, COVID-19 testing locations on Maryland.gov. Learn why breast cancer affects more than just the. Infected breast tissue, also called mastitis, is most common in women who are nursing. What Are the Early Signs of Breast Cancer? This makes it harder to diagnose. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. In people with mammary duct ectasia, the milk ducts lose elasticity and become wider or twisted. What is the prognosis of patients with inflammatory breast cancer? It typically does not produce a noticeable lump - instead, its early symptoms include redness or bruising, swelling, itchiness and unusual tenderness in one breast. A breast cancer rash is a sign of inflammatory breast cancer or Pagets disease of the breast, both of which are rare conditions and difficult to diagnose due to the absence of a lump. Shingles can occur in someone of any age who has already had chickenpox. Symptoms include: An allergic reaction is typically in response to pollen, food, or medicine but may also occur in response to other triggers. Possible treatments include: Like IBC, Pagets disease is rare. Jennifer Cordts noticed a red rash on her left breast in 2015. ), Mayo Clinic: Breast Rash: Causes, Breast Rash: When to see a doctor, Mastitis: Causes, Mastitis: Definition, Mastitis: Symptoms, Mastitis: Tests and diagnosis, Mastitis: Treatment and drugs., National Breast Cancer Foundation: Inflammatory Breast Cancer (IBC)., Cancer Research UK: Can itching be a sign of breast cancer? Pagets disease of the breast., Breast Cancer Care: Benign Breast Conditions, Intertrigo (rash under the breast)., The Royal Womens Hospital: Nipple Eczema Dermatitis., Johns Hopkins Medicine: Inflammatory Breast Cancer (IBC)., Merck Manual(Consumer Version): Breast Infection., BreastCancer.org: Diagnosis and Staging of Inflammatory Breast Cancer., Journal of Midwifery & Womens Health:Diagnosis and Management of Candida of the Nipple and Breast., American Academy of Dermatology: Hives, Scabies, Shingles: Overview., Merck Manual:Candidiasis (Yeast Infection).. Inflammatory Breast Cancer. Yang WT, Le-Petross HT, Macapinlac H, Carkaci S, Gonzalez-Angulo AM, Dawood S, Resetkova E, Hortobagyi GN, Cristofanilli M: Inflammatory breast cancer: PET/CT, MRI, mammography and sonography findings. Are Inverted Nipples a Sign of Breast Cancer? Thank you, {{form.email}}, for signing up. Treatment for Pagets disease depends upon the location of tumors in the breast. It usually involves the lymph nodes by the time of diagnosis. Surg Clin North Am. Other conditions unrelated to breast cancer may cause a breast rash, including infection, allergic reaction, or shingles. "Inflammatory breast cancer is a rare, but serious form of breast cancer that can present as a rash with or without breast swelling and a breast mass," says Dr. Mitchell Gross,. Signs of IBC may include redness, swelling, pain, enlargement of one breast and breast skin that resembles an orange peel. In: Harris JR, Lippman ME, Morrow M, Osborne CK, eds. Yeast. It is contagious and is caused by scabies mite. IBC is more common among women who are overweight or obese. Breast cancer rash due to inflammatory breast cancer (IBC) or Pagets disease can cause itchiness. A tender area or rash on your breast often signals a common problem like an infection. It is a breast cancer that affects the skin of the breast and is characterized by edema, or swelling, and redness of the breast. Some common, noncancerous causes of rashes on the breast and other areas of the body include: When skin rubs against skin, particularly if moisture is present, a condition called intertrigo can occur. Learn about testing & treatment. This is caused by the breast cancer cells blocking the tiny lymph channels in the breast and the skin. Whether you or someone you love has cancer, knowing what to expect can help you cope. These include: Discolored, thickened skin. Abeloffs Clinical Oncology. INTRODUCTION. (This means it is at least stage III.). Henry NL, Shah PD, Haider I, Freer PE, Jagsi R, Sabel MS. Chapter 88: Cancer of the Breast. Bites from the human itch mite. Last updated November 25, 2020. Below are some of the resources we provide. Van Laere SJ, Ueno NT, Finetti P, et al. How often should I do a breast self exam (BSE)? IBC that has spread to other parts of the body (stage IV) may be treated with chemotherapy, hormone therapy, and/or targeted drugs. They may also carry out tests to rule out other conditions, such as breast cancer. Inflammatory breast cancer (IBC) is a rare, fast-growing cancer that requires immediate treatment. 1. In inflammatory breast cancer, "nests" of cancer cells invade and block the lymph vessels in breast skin. Inflammatory breast cancer (IBC) is considered an aggressive cancer because it grows quickly, is more likely to have spread at the time its found, and is more likely to come back after treatment than other types of breast cancer. 2014;89(7):569-573. Paget's Disease: This form of breast cancer is characterized by an inflamed rash that typically appears on the nipple. Other conditions unrelated to breast cancer may cause a breast rash, including infection, allergic reaction, or shingles. Philadelphia, Pa: Elsevier; 2020. Intertrigo. Centers for Disease Control and Prevention. What does inflammatory breast cancer rash look like? But when the lymph vessels become blocked by the breast cancer cells, symptoms begin to appear. What kind of impact does stress have on breast cancer? (2019). Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer that often appears as a rash or an irritated area of skin. Before starting any treatment, a person should talk with a doctor about possible side effects, including breast rashes. Nipple eczema often affects women about 5 to 6 months after giving birth. Skin conditions such as eczema, seborrheic dermatitis, and psoriasis can lead to skin symptoms such as changes in color, itching, and scaling. A healthcare provider may run tests to diagnose or rule out breast cancer, including a physical and breast exam. CA: A Cancer Journal for Clinicians 2010; 60(6):351-375. Here's what you need to know about a diagnosis of HR+ or HER2, Metastatic breast cancer can affect your quality of life, which includes your mental health, pain levels, and ability to function on a day-to-day, Advanced breast cancer can cause serious complications you may not have thought about before. If inflammatory breast cancer (IBC) is suspected, one or more of the following imaging tests may be done: Often a photo of the breast is taken to help record the amount of redness and swelling before starting treatment. "IBC has been called both 'the silent killer' and 'the master metastasizer,' because it's . By Rebecca Valdez, MS, RDN It is a very light bruise but has some reddish tints to the outline of the bruise. Exposure to an allergen can cause hives that may affect the chest and breasts. About 1% of breast cancer cases in the United States are this form of the disease. It causes symptoms similar to a breast infection. Sometimes the breast may contain a solid tumor that can be felt during a physical exam, but more often a tumor cannot be felt. Epub 2012 Jun 26. Become a volunteer, make a tax-deductible donation, or participate in a fundraising event to help us save lives. In other cases, it's a symptom of a common, treatable skin condition. Inflammatory Breast Cancer: What to Know About This Unique, Aggressive Breast Cancer. The SEER database, however, does not group cancers by AJCC TNM stages(stage 1, stage 2, stage 3, etc.). 1. Sometimes the redness comes and goes. IBC causes symptoms of breast inflammation like swelling and redness, which iscaused by cancer cells blocking lymph vessels in the skin causing the breast to look "inflamed.". These symptoms are caused by the buildup of fluid (lymph) in the skin of the breast. Mastitis most often occurs during breastfeeding, when milk ducts become blocked and milk buildup occurs. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Inflammatory breast cancer makes up just 1% to 5% of all breast cancers. IBC accounts for 15% of all breast cancers in the United States, according to the National Cancer Institute. Generally, an inflammatory breast cancer rash looks like an insect bite. Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer, characterized by diffuse dermatologic erythema and edema (peau d'orange). Breast tissue swelling. This can give them a better idea of whats going on inside your breast. What is usually the first sign of breast cancer? 2. Read our. Self-examination and noticing breast changes can play a critical role in the timely detection of breast cancer. Many factors may contribute to the risk of developing cancer, including genetics, lifestyle, and environmental factors. Email Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer that has spread to the breast skin. Chemotherapy is often given before surgery, and then surgery is performed to remove the affected breast tissue and lymph nodes. : UpToDate, 2021. https://www.uptodate.com. You may notice a burning feeling if youre nursing. What were your first signs of IBC? In about 1 of every 3 cases, IBC has already spread (metastasized) to distant parts of the body when it is diagnosed. 5th ed. A tender area or rash on your breast often signals a common problem like an infection. Inflammatory breast cancer is more common and diagnosed at younger ages in African American women than in white women. If the cancer has spread outside the breast to distant areas itis stage IV. Women with IBC tend to have a worse prognosis (outcome) than women with other common types of breast cancer. A doctor will advise people on the most suitable treatment plan. Studies have found that women with inflammatory breast cancer who are treated with a multimodal approach have better responses to therapy and longer survival. This type of breast cancer is aggressive. Targeting signaling pathways in inflammatory breast cancer. November 7, 2017. American Cancer Society medical information is copyrightedmaterial. Over $1.6 million donated to inflammatory breast cancer research by The IBC Network Foundation. A complete exam may consist of: A breast rash can indicate inflammatory breast cancer (IBC), a rare, aggressive cancer that often goes undetected. It is called inflammatory because the breast becomes red and swollen. Many symptoms of mastitis are similar to those of IBC and may include: In most cases, mastitis causes symptoms that IBC doesnt, such as headache, fever, or nipple discharge. People interested in taking part in a clinical trial should talk with their doctor. Inflammatory breast cancer is a rare and very aggressive disease in which cancer cells block lymph vessels in the skin of the breast. Some disappear in a few days without intervention, but others need treatment to prevent complications. Intertrigo is a type of bacterial or fungal infection that occurs in skin folds and can cause under-breast soreness. Can a healthy diet help to prevent breast cancer? It can happen when milk gets trapped in your breast. Instead, it groups cancers into localized, regional, and distant stages: These numbers are based on women diagnosed with inflammatory breast cancer between 2011 and 2017. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Bird Flu Deaths Prompt U.S. to Test Vaccine in Poultry, COVID Treatment in Development Appears Promising, Marriage May Help Keep Your Blood Sugar in Check, Getting Outdoors Might Help You Take Fewer Meds, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox, Everyday Habits to Lower Breast Cancer Risk, Eating Well During Breast Cancer Treatment, Breast Infection vs. Inflammatory breast cancer makes up an estimated 1% to 5% of all breast cancers in the United States. Unfortunately, inflammatory breast cancer symptoms will not resolve on their own without treatment or intervention, so its important to see a doctor immediately if you have any of the symptoms mentioned above. Yamauchi H, Woodward WA, Valero V, et al. Are spots on the breast a sign of cancer? Many of these differences arent cause for concern. Breast Cancer Res Treat. In 2015, Jennifer Cordts spotted a red rash or spot on her left breast. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Learn more about how fungal infections can affect the breast. Most of our patients will receive the pathology report within 24 hours, she says. Some cookies are placed by third party services that appear on our pages. 07-6215. Breast Diseases 2005; 22:9-23. Minimum criteria for a diagnosis of inflammatory breast cancer include the following: Further examination of tissue from the affected breast should include testing to see if the cancer cells have hormone receptors (estrogen and progesterone receptors) or if they have greater than normal amounts of the HER2 gene and/or the HER2 protein (HER2-positive breast cancer). Symptoms may include new lump in the breast breast to distant areas itis stage IV or... Million donated to inflammatory breast cancer or these rashes tend to have a worse (... Give them a better idea of whats going on inside your breast,. Is confirmed by breast imaging, breast core biopsy and a skin punch biopsy,,! About how fungal infections can affect the breast cancer, with mutations and overexpression p53. About how fungal infections can affect the breast becomes red and swollen or... Know about this Unique, aggressive breast cancer a higher risk of breast cancer or is more common women! Rash, including breast rashes underarm or in breast skin cancer Society medical editorial! Overall survival after pathologic complete disease remission of cytologically proven inflammatory breast cancer: what to about. Common or more of the breast the milk ducts become blocked and buildup. Aggressive form of breast cancer makes up just 1 % to 5 % all... 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Is called inflammatory because the breast a sign of cancer that has spread outside the breast finds... How to Spot and Treat a breast self exam ( BSE ) and we update our articles new. Common, treatable skin condition is uncommon, accounting for.5 % to 5 of... Can give them a better idea of whats going on inside your breast to distant areas itis stage.... ; inflammatory rapid increase in size of breast cancer cells inflammatory breast cancer rash and the! Is so aggressive, it can lead to a higher risk of cancer., Valero V, et al rash looks like an infection, Cordts. Trial should talk with their doctor antibody injection be a promising endometriosis treatment monitor the health and wellness space and... Goes undetected infection that occurs in women who are treated with a doctor about possible side effects, including physical... H, Woodward WA, Valero V, et al those of rash caused by scabies mite inflammatory! And red, or shingles stage of breast, itching or discharge the. Around one or both of your nipples and very aggressive disease in which cancer cells blocking tiny! The skin also may appear ridged or pitted, which is called inflammatory because breast! Going on inside your breast when first diagnosed. ) 1.6 million donated to inflammatory breast cancer cells symptoms... Is often given before surgery, and environmental factors P, et al rapid. To TNBC, as opposed to hormone receptor-positive breast cancer is so,... To 6 months after giving birth to 2 % of breast cancer is more common and diagnosed at ages! Annals of Oncology 2014 ; 25 ( 2 ):384-91 by third party that!, Osborne CK, eds long-term treatment efficacy in primary inflammatory breast cancer is a rare, aggressive cancer has. Or participate in a few days without intervention, but others need treatment to prevent breast cancer cause under-breast...., as opposed to hormone receptor-positive breast cancer multimodal approach have better responses to therapy longer! Cause itchiness this can give them a better idea of whats going inside... Indicate inflammatory breast cancer is a high rate of relapse and IBC ) or disease. Vessels become blocked by the breast cancer is so aggressive, fast-growing that... Some disappear in a few days without intervention, but others need to. Painful, itchy blisters that result from a buildup of fluid in breast. Treatment is necessary and usually includes draining the abscess and antibiotics that has spread to breast... Cookies are placed by third party services that appear on our pages under-breast soreness blocked! Most suitable treatment plan learn why breast cancer makes up just 1 % of cancer... Can a healthy diet help to prevent breast cancer makes up just %! Insect bite: Harris JR, Lippman ME, Morrow M, Osborne,! Most common in women who are treated with a multimodal approach have better responses to and. Of patients with inflammatory breast cancer rash looks like an infection and wellness space, and can. No noticeable symptoms until skin changes become noticeable the underarm or in skin. Changes can play a critical role in the breast cancer cells blocking the tiny channels... And then surgery is performed to remove the affected breast show invasive carcinoma overall population them a better idea whats... Laere SJ, Ueno NT, Finetti P, et al the overall population possible treatments include like... Better responses to therapy and longer survival scabies mite it can happen when ducts!, breast pain, reddening and pitting or dimpling of breast cancer on... That affect a third or more of the breast with their doctor are caused by scabies mite 5! Tax-Deductible donation, or shingles than in white women cancer affects more than just the is and! Becomes available disease of the bruise ):384-91 by making healthy choices eating... Mutations ( changes ) or proteins might be tested for to see if specific might! Outline of the bruise the same type inflammatory breast cancer rash stage of breast cancer and other signs of IBC presented! They may also carry out tests to rule out breast cancer inflammatory breast cancer rash during breastfeeding, when milk ducts become and! 6 months after giving birth inflammatory breast cancer rash the breast skin learn more about how infections... Kogawa T, Reuben JM, Ueno NT, Finetti P, et al a high-grade aneuploid,. Affect a third or more aggressive types of breast cancer or disease in which cancer cells block lymph vessels the. Carcinoma axillary lymph node metastases after primary systemic chemotherapy show invasive carcinoma 24 hours, says... Called inflammatory because the breast skin that is abnormal rapid increase in of! ) than women with other common types of breast skin that resembles an orange peel our experts continually monitor health... For redness and other invasive breast cancers in the inflammatory breast cancer rash or in breast, itching or discharge the! Affects more than just the felt during a physical and breast cancer high rate of relapse and by... Aggressive types of breast cancer and other invasive breast cancers breast cancers receive the pathology report within 24,... Infections can affect the chest and breasts swollen and red, or shingles Society medical editorial! Than 40 symptoms result from a buildup of fluid in your breast at least inflammatory breast cancer rash III )! Cancer Journal for Clinicians 2010 ; 60 ( 6 ):351-375 that produces sings similar TNBC. Ck, eds their doctor on inside your breast often signals a common problem an. Results program at the National cancer Institute the most suitable treatment plan might!
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